Psst! I've posted some details about my notebook setup here.
NCBI's Sequence Read Archive is the go-to repository for published genome-scale sequence data sets.
Although there are a variety of ways to download sequence data from SRA, the
fastq-dump command from the SRA Toolkit is the most convenient in my opinion.
In fact, with a few settings tweaks
fastq-dump can stream data directly from the SRA into an analysis ...